Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8 Years

Article type: Research Article

Authors: Bjerke, Maria^{b; 1} | Kern, Silke^{a; b; 1; *} | Blennow, Kaj^b | Zetterberg, Henrik^{b; c} | Waern, Margda^a | Börjesson-Hanson, Anne^a | Östling, Svante^a | Kern, Jürgen^a | Skoog, Ingmar^a

Affiliations: [a] Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden | [b] Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden | [c] UCL Institute of Neurology, Queen Square, London, UK

Correspondence: [*] Correspondence to: Silke Kern, MD, PhD, Neuropsychiatric Epidemiology Unit, Sahlgrenska University Hospital/Mölndal, Wallinsgatan 6, SE 43141 Mölndal, Sweden. Tel.: +46 31 342 2164; Fax: +46 31 828163; E-mail: silke.kern@neuro.gu.se

Note: [1] These authors contributed equally to this work.

Abstract: Background:Increased fatty acid-binding protein 3 (FABP-3) levels have been reported in neurodegenerative diseases, including Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) FABP-3 has therefore been proposed as a putative marker for dementia. Population-based studies examining whether CSF FABP-3 predicts later development of dementia are lacking. Objective:The aim of this study was to examine CSF levels of FABP-3 in relation to later development of dementia in elderly women and in relation to Aβ42, T-tau, P-tau181, and CSF: serum albumin ratio. Methods:86 non-demented women aged 70–84 years who participated in the Prospective Population Study of Women in Gothenburg, Sweden took part in a lumbar puncture in 1992–93. CSF-FABP-3, Aβ42, T-tau, P-tau181, and the CSF: serum albumin ratio were measured at baseline. Participants were examined with a neuropsychiatric exam at baseline and at follow-up in 2000. Dementia was diagnosed in accordance with DSM-III-R criteria. Results:Between 1992 and 2000, 8 women developed dementia (4 AD, 3 vascular dementia, 1 mixed vascular dementia and AD). Higher levels of CSF-FABP-3 at baseline were related to development of dementia (OR 1.36 CI [1.05–1.76] p = 0.022) and the subtype AD (OR 1.38 CI [1.06–1.82), p = 0.019) during follow-up. FABP-3 correlated with CSF T-tau (r = 0.88, p <  0.001), P-tau181 (r = 0.619, p <  0.001), and CSF:serum albumin ratio (r = 0.233, p = 0.031), but not with Aβ42 (r = –0.08, p = 0.444) Conclusion:CSF FABP-3 may be an early marker for later development of dementia, probably related to neuronal degeneration, but independent of Aβ metabolism.

Keywords: Cerebrospinal fluid, dementia, fatty acid binding protein-3, older women, population-based, prospective

DOI: 10.3233/JAD-150525

Journal: Journal of Alzheimer's Disease, vol. 49, no. 3, pp. 733-741, 2016