Affiliations: [a] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China | [b] Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China | [c] German Center for Neurodegenerative Diseases, Munich, Germany | [d] Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany | [e] Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
Correspondence:
[*]
Correspondence to: Dr. Ming-wei Zhu and Dr. Lu-ning Wang, Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing 100853, China. Tel.: 0086 10 66876268; Fax: 0086 10 68229325; zhumw301@163.com (Ming-wei Zhu); ln_wang301@163.com. (Lu-ning Wang)
Abstract: A clinicopathological investigation was conducted on a case of an 89-year-old man with a 10-year history of progressive dementia who also suffered strokes, apathy, aphasia, dysarthria, weakness of both legs, and walking difficulties. At autopsy, we found an obvious atrophy of the frontal and temporal cortex. Lewy bodies (LBs) could be seen in brain stem, amygdala, and neocortex. Argyrophilic grains were observed in hippocampus, entorhinal cortex, neocortex, amygdala, and pons, as well as neurofibrillary tangles in the entorhinal cortex and hippocampus. The case presented here is a rare case of frontotemporal lobar degeneration with accumulation of argyrophilic grains and Lewy bodies.
