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Issue title: Alzheimer's Disease: Detection, Prevention, and Preclinical Treatment
Guest editors: Jack C. de la Torre
Article type: Review Article
Authors: Anstey, Kaarin J.a; * | Eramudugolla, Ranmaleea | Dixon, Roger A.b
Affiliations: [a] Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, ACT, Australia | [b] Department of Psychology, University of Alberta, Edmonton, AB, Canada
Correspondence: [*] Correspondence to: Kaarin J. Anstey, Centre for Research on Ageing, Health and Wellbeing, 63 Eggleston Road, The Australian National University, Canberra, ACT 0200, Australia. Tel.: +612 61258410; Fax: +612 61251558; E-mail: kaarin.anstey@anu.edu.au.
Abstract: The development and integration of risk assessment and clinical risk management for Alzheimer's disease (AD) and dementia is a rapidly emerging field of research and practice. At present, risk management is the only available approach with potential for a large impact on the projected rates of dementia, given population aging. This review describes six available risk assessment tools, including those developed specifically for AD and those for dementia. These tools differ along several important dimensions, including whether they (a) include clinical measures, (b) require a clinician's ratings, (c) are predominantly self-report, (d) are independently validated, and (e) are available online. A narrative review of recently identified risk factors not included in these instruments is included, indicating future directions for risk assessment. Finally, consideration is given to the prioritization of risk advice according to the ease of risk modification and the potential for synergies among risk factors.
Keywords: Alzheimer's disease, cognitive decline, prevention, risk assessment, risk factor
DOI: 10.3233/JAD-141248
Journal: Journal of Alzheimer's Disease, vol. 42, no. s4, pp. S463-S473, 2014
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