Peripheral Amyloid Levels Present Gender Differences Associated with Aging in AβPP/PS1 Mice

Article type: Short Communication

Authors: Ordóñez-Gutiérrez, Lara | Antón, Marta | Wandosell, Francisco^{; *}

Affiliations: Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), C/ Nicolás Cabrera 1, Universidad Autónoma Madrid, Madrid, Spain

Correspondence: [*] Correspondence to: Francisco Wandosell, PhD, Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM & CIBERNED, Universidad Autónoma de Madrid, C/ Nicolás Cabrera 1, 28049 Madrid, Spain. Tel.: +34 911 964 561; Fax: +34 911 964 420; E-mail: fwandosell@cbm.csic.es.

Abstract: The accumulation of amyloid-β (Aβ) peptide is one of the major neuropathological hallmarks of Alzheimer's disease (AD). We have analyzed whether the progression of amyloidosis differentially affects males and females along aging in AβPP/PS1 transgenic mice. The levels of peripheral amyloid, Aβ40 and Aβ42, are not modified in either sex until 9 months of age. After that, however, there is an increase in amyloid levels in plasma among females and a decrease among males. These findings could be essential to design gender-specific strategies in other in vivo experiments or even in AD treatments.

Keywords: Aging, Alzheimer's disease models, amyloid-β, AβPP/PS1, peripheral amyloid, transgenic mice

DOI: 10.3233/JAD-141158

Journal: Journal of Alzheimer's Disease, vol. 44, no. 4, pp. 1063-1068, 2015