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Article type: Research Article
Authors: Yakhia, Majaa; b | König, Alexandraa; c | van der Flier, Wiesje M.b | Friedman, Leahd | Robert, Philippe H.a; e | David, Renauda; e; *
Affiliations: [a] EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France | [b] Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands | [c] School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The Netherlands | [d] VA Palo Alto Health Care System, Palo Alto, CA, USA | [e] Centre Mémoire de Ressources de Recherche – CHU University of Nice Sophia Antipolis, Nice, France
Correspondence: [*] Correspondence to: Renaud David, Cimiez Hospital, 4 Avenue Reine Victoria, 06003 Nice, France. Tel.: +33 4 92034770; Fax: +33 4 92034772; E-mail: david.r@chu-nice.fr.
Abstract: Background:Individuals with mild cognitive impairment (MCI) may exhibit changes in motor activity in conducting their activities of daily living. Depression, one of the most frequent neuropsychiatric symptoms, might affect motor activity in MCI. Objective:To assess motor activity in MCI subjects carrying out short functional activity tasks using ambulatory actigraphy. Secondly, we sought to investigate the influence of depressive symptoms on motor activity. Methods:20 MCI and 14 healthy subjects carried out a 30-minute standardized scenario while wearing a chest actigraph. The protocol consisted of directed activities (execution of motor tasks), semi-directed activities (execution of Instrumental Activities of Daily Living, IADL), and undirected ‘free’ activities. Several common assessment scales (GDS, MADRS, and NPI) were used to diagnose depression. Results:MCI subjects had significantly reduced mean motor activity while carrying out directed and semi-directed activities, compared to healthy control subjects. No difference was found in motor activity between MCI subjects with or without depression. Conclusion:Actigraphic measurement of motor activity during the evaluation of IADLs and motor tasks is a potential objective tool in detecting early changes in MCI. Depressive symptoms seem not to be associated with motor activity in MCI subjects.
Keywords: Actigraphy, depressive symptoms, mild cognitive impairment, motor activity
DOI: 10.3233/JAD-131691
Journal: Journal of Alzheimer's Disease, vol. 40, no. 4, pp. 869-875, 2014
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