Affiliations: [a] Neuroscience Research Australia, Sydney, NSW, Australia | [b] School of Medical Sciences, University of New South Wales, NSW, Australia | [c] Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia | [d] Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK | [e] Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
Correspondence:
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Correspondence to: Dr. Michael Hornberger, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK. Tel.: +44 1223 760694; Fax: +44 1223 760694; E-mail: mh755@medschl.cam.ac.uk.
Abstract: Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.
