Affiliations: [a] Neuroscience Research Australia, Randwick, Sydney, Australia | [b] School of Medical Sciences, The University of New South Wales, Sydney, Australia | [c] Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia | [d] School of Psychology, The University of New South Wales, Sydney, Australia
Correspondence:
[*]
Correspondence to: Dr. Muireann Irish, Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia. Tel.: +61 2 9399 1602; Fax: +61 2 9399 1047; E-mail: m.irish@neura.edu.au.
Abstract: Background:Prospective memory (PM) is the ability to remember to execute an intended action either at a future time (Time-based PM) or when a specific event occurs (Event-based PM). Previous studies demonstrate impaired PM in Alzheimer’s disease (AD); however, the status of PM in frontotemporal dementia (FTD) remains unknown. Objective:To examine PM performance and its associated cognitive mechanisms, in two subtypes of FTD: semantic dementia (SD) and the behavioral variant of FTD (bvFTD), in comparison with matched AD and control participants. Methods:Twenty-four dementia patients (SD = 8; bvFTD = 8; AD = 8) and 12 age- and education-matched controls underwent a shortened version of the Cambridge Behavioural Prospective Memory Test, as well as a standard neuropsychological test battery. Results:Compared to controls, SD patients exhibited preserved Time-based PM in the context of impaired Event-based PM, with the latter strongly associated with deficits in semantic processing. In contrast, bvFTD and AD patients demonstrated global PM impairments irrespective of subscale, which strongly correlated with deficits in delayed episodic retrieval for both groups. Caregiver reports of stereotypical behaviors were associated with compromised Event-based PM in SD and Time-based PM in bvFTD, with no such relationship evident in AD. Conclusion:This is the first study to investigate prospective memory in FTD syndromes. A relative sparing of Time-based PM was observed in SD, in contrast with global PM deficits in bvFTD. Disrupted PM processing was found to correlate with stereotypical behaviors in FTD syndromes, a finding that we suggest is worthy of further investigation.
