Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

Article type: Research Article

Authors: Harris, Sarah E.^{a; b; *} | Davies, Gail^{a; b; c} | Luciano, Michelle^{b; c} | Payton, Antony^d | Fox, Helen C.^e | Haggarty, Paul^f | Ollier, William^d | Horan, Michael^g | Porteous, David J.^{a; b} | the Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium¹ | Starr, John M.^{b; h} | Whalley, Lawrence J.^e | Pendleton, Neil^g | Deary, Ian J.^{b; c}

Affiliations: [a] Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK | [b] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK | [c] Department of Psychology, University of Edinburgh, Edinburgh, UK | [d] Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Manchester, UK | [e] Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK | [f] Division of Lifelong Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, UK | [g] Centre for Clinical and Cognitive Neuroscience. Institute Brain Behaviour and Mental Health, University of Manchester, Clinical Sciences Building, Salford Royal NHS Foundation Trust, Salford, UK | [h] Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK

Correspondence: [*] Correspondence to: Sarah E. Harris, Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Tel.: +44 0131 651 1070; Fax: +44 0131 651 1771; E-mail: Sarah.Harris@igmm.ed.ac.uk.

Note: [1] Data used in the preparation of this article were obtained from the Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium. As such, the investigators within the GERAD1 consortia contributed to the design and implementation of GERAD1 and/or provided data but did not participate in analysis or writing of this report. A full list of GERAD1 investigators can be found in the acknowledgments.

Keywords: Aging, Alzheimer's disease, cognition, cohort studies, genetics, polygenic traits

DOI: 10.3233/JAD-131058

Journal: Journal of Alzheimer's Disease, vol. 39, no. 3, pp. 565-574, 2014