Affiliations: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA
Correspondence:
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Correspondence to: Renã A.S. Robinson, 111 Eberly Hall, 200 University Drive, Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. Tel.: +1 412 624 8167; Fax: +1 412 624 8611; E-mail: rena@pitt.edu.
Abstract: Oxidative stress plays a role in Alzheimer's disease (AD) with elevated levels being present in tissues such as brain, plasma, and cerebrospinal fluid. The role of oxidative stress in the immune system of AD is less established. Therefore, we measured protein markers of oxidative stress—protein carbonyls (PCO) and 3-nitrotyrosine (3NT)—in CD90+ T-cells of a double-transgenic AD mouse model. Higher levels of PCO and 3NT were detected in amyloid-β protein precursor/presenilin-1 (AβPP/PS-1) mice and increased with disease progression. These studies provide evidence that oxidative stress in the immune system may be useful for understanding disease pathogenesis.
