Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Huber, Bertrand R.a; 1 | Meabon, James S.b; c; 1 | Martin, Tobin J.c | Mourad, Pierre D.d; e; f | Bennett, Raymondg | Kraemer, Brian C.c; h | Cernak, Iboljai | Petrie, Eric C.a; b | Emery, Michael J.j | Swenson, Erik R.j; k | Mayer, Cynthiaa | Mehic, Edinf | Peskind, Elaine R.a; b | Cook, David G.c; h; l; *
Affiliations: [a] Northwest Network Mental Illness, Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA | [b] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA | [c] Geriatric Research, Education, and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA | [d] Department of Neurological Surgery, University of Washington, Seattle, WA, USA | [e] Applied Physics Laboratory, University of Washington, Seattle, WA, USA | [f] Department of Bioengineering, University of Washington, Seattle, WA, USA | [g] Baker Engineering and Risk Consultants, San Antonio, TX, USA | [h] Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA | [i] Canadian Military and Veterans' Clinical Rehabilitation, Faculty of Rehabilitation Medicine, University of Alberta, AB, Canada | [j] Pulmonary and Critical Care Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA | [k] Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA | [l] Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA
Correspondence: [*] Correspondence to: David G. Cook, PhD, 1660 S. Columbian Way, Seattle, WA 98108, USA. Tel.: +1 206 768 5437; E-mail: dgcook@u.washington.edu.
Note: [1] These authors contributed equally to this manuscript.
Abstract: Mild traumatic brain injury (mTBI) is considered the ‘signature injury’ of combat veterans that have served during the wars in Iraq and Afghanistan. This prevalence of mTBI is due in part to the common exposure to high explosive blasts in combat zones. In addition to the threats of blunt impact trauma caused by flying objects and the head itself being propelled against objects, the primary blast overpressure (BOP) generated by high explosives is capable of injuring the brain. Compared to other means of causing TBI, the pathophysiology of mild-to-moderate BOP is less well understood. To study the consequences of BOP exposure in mice, we employed a well-established approach using a compressed gas-driven shock tube that recapitulates battlefield-relevant open-field BOP. We found that 24 hours post-blast a single mild BOP provoked elevation of multiple phospho- and cleaved-tau species in neurons, as well as elevating manganese superoxide-dismutase (MnSOD or SOD2) levels, a cellular response to oxidative stress. In hippocampus, aberrant tau species persisted for at least 30 days post-exposure, while SOD2 levels returned to sham control levels. These findings suggest that elevated phospho- and cleaved-tau species may be among the initiating pathologic processes induced by mild blast exposure. These findings may have important implications for efforts to prevent blast-induced insults to the brain from progressing into long-term neurodegenerative disease processes.
Keywords: Blast-induced neurotrauma, brain trauma, cerebellum, mitochondrial oxidative stress, neurodegeneration, tauopathy
DOI: 10.3233/JAD-130182
Journal: Journal of Alzheimer's Disease, vol. 37, no. 2, pp. 309-323, 2013
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl