Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

Article type: Research Article

Authors: Chien, David T.^a | Bahri, Shadfar^b | Szardenings, A. Katrin^a | Walsh, Joseph C.^a | Mu, Fanrong^a | Su, Min-Ying^b | Shankle, William R.^c | Elizarov, Arkadij^a | Kolb, Hartmuth C.^{a; *}

Affiliations: [a] Siemens Molecular Imaging, Inc., Culver City, CA, USA | [b] Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, CA, USA | [c] Shankle Clinic Memory and Cognitive Disorders Program, Hoag Neurosciences Institute, Newport Beach, CA, USA

Correspondence: [*] Correspondence to: Hartmuth C. Kolb, Siemens Molecular Imaging, Inc., 6100 Bristol Parkway, Culver City, CA 90230, USA. Tel.: +1 310 804 7324; Fax: +1 310 744 4879; E-mail: hckolb@me.com.

Abstract: Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.

Keywords: Alzheimer's disease, amyloid-β, brain imaging, mild cognitive impairment, molecular imaging, neurofibrillary tangles, paired helical filaments, tau, tau aggregates, tauopathy

DOI: 10.3233/JAD-122059

Journal: Journal of Alzheimer's Disease, vol. 34, no. 2, pp. 457-468, 2013