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Article type: Research Article
Authors: Capsoni, Simonaa; b | Carlo, Anne-Sophiec | Vignone, Domenicob | Amato, Gianlucab | Criscuolo, Chiarab; d | Willnow, Thomas E.c | Cattaneo, Antoninoa; b; *
Affiliations: [a] Laboratory of Neurobiology, Scuola Normale Superiore, Pisa, Italy | [b] Neurotrophins and Neurodegenerative diseases Unit, European Brain Research Institute, Rome, Italy | [c] Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany | [d] Department STB, University of L'Aquila, L'Aquila, Italy
Correspondence: [*] Correspondence to: Prof. Antonino Cattaneo, Laboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy. Tel.: +39 050509320; Fax: +39 0503152220; E-mail: antonino.cattaneo@sns.it.
Abstract: Sortilin-related receptor with A-type repeats (SorLA, also known as LR11) has been implicated in Alzheimer's disease (AD). Thus, genetic studies associated SorLA gene variants with the risk of sporadic AD. Also, in vitro and in vivo studies showed that SorLA impairs processing of the amyloid-β protein precursor (AβPP) to amyloid-β. In particular, it has been found that loss of SorLA accelerates senile plaque deposition in mouse models overexpressing mutant forms of human AβPP and presenilin 1. Here we tested the possibility that SorLA deficiency also interferes with behavioral and neuropathological endpoints in an alternative murine AD model, the AD10 anti-nerve growth factor (NGF) mouse, in which amyloid-β accumulation derives from the altered processing of endogenous AβPP. In addition to alterations in AβPP processing, AD10 mice also show cholinergic deficit and tau hyperphosphorylation resulting in behavioral deficits in learning and memory paradigms. We found that the loss of SorLA not only exacerbates early amyloid pathology but, at the same time, protects from cholinergic deficit and from early phospho-tau mislocalization. The results show that in the AD10 anti-NGF mouse model the AβPP processing-related aspects of neurodegeneration can be dissociated from those related to tau posttranslational processing and to cholinergic phenotypic maintenance by modulation of SorLA expression. We suggest that SorLA regulates different aspects of neurodegeneration in a complex way, supporting the hypothesis that SorLA expression might be critical not only for amyloid-related pathology but also for other cellular processes altered in AD.
Keywords: Amyloid, anti-NGF, cholinergic deficit, memory impairment, LR11, SorLA, tau, TrkA
DOI: 10.3233/JAD-2012-121399
Journal: Journal of Alzheimer's Disease, vol. 33, no. 2, pp. 357-371, 2013
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