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Article type: Short Communication
Authors: O'Dowd, Seán T.a; b | Ardah, Mustafa T.c | Johansson, Perd; e | Lomakin, Alekseyf | Benedek, George B.f | Roberts, Kinley A.b | Cummins, Gemmab | El Agnaf, Omar M.c | Svensson, Johane; g | Zetterberg, Henrikh | Lynch, Timothyb | Walsh, Dominic M.a; *
Affiliations: [a] Laboratory for Neurodegenerative Research, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Republic of Ireland | [b] Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Republic of Ireland | [c] Faculty of Medicine and Health Sciences, Department of Biochemistry, United Arab Emirates University, Al Ain, United Arab Emirates | [d] Department of Neuropsychiatry, Skaraborg Hospital, Falköping, Sweden | [e] Department of Endocrinology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden | [f] Department of Physics and Center for Material Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA | [g] Department of Endocrinology, Skaraborg Hospital, Skövde, Sweden | [h] Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
Correspondence: [*] Correspondence to: Dominic M. Walsh, Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Harvard Institutes of Medicine (Room 921b), 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Tel.: +1 617 5255059; Fax: +1 617 5255252; E-mail: dwalsh3@partners.org.
Abstract: Elevated cerebrospinal fluid concentrations of tau discriminate Alzheimer's disease from other neurodegenerative conditions. The reasons for this are unclear. While commercial assay kits are widely used to determine total-tau concentrations, little is known about their ability to detect different aggregation states of tau. We demonstrate that the leading commercial enzyme-linked immunosorbent assay reliably detects aggregated and monomeric tau and evinces good recovery of both species when added into cerebrospinal fluid. Hence, the disparity between total-tau levels encountered in Alzheimer's disease and other neurodegenerative conditions is not due to differential recognition of tau assembly forms or the extent of degeneration.
Keywords: Alzheimer's disease, cerebrospinal fluid, ELISA, tau
DOI: 10.3233/JAD-2012-121393
Journal: Journal of Alzheimer's Disease, vol. 33, no. 4, pp. 923-928, 2013
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