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Issue title: Physiopathology of Vascular Risk Factors in Alzheimer's Disease
Guest editors: Jack de la Torre
Article type: Review Article
Authors: Polidori, M. Cristinaa; * | Pientka, Ludgera | Mecocci, Patriziab
Affiliations: [a] Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, Herne, Germany | [b] Department of Geriatrics, Perugia University Hospital, Perugia, Italy
Correspondence: [*] Correspondence to: Prof. Dr. M. Cristina Polidori, Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, Widumer Str. 8, 44627 Herne, Germany. E-mail: polidori@uni-duesseldorf.de.
Abstract: The present review is dedicated to the epidemiology of vascular risk factors proven to play a role in facilitating onset and progression of cognitive impairment. These include hypertension, hypercholesterolemia, diabetes, obesity, atherosclerosis, and cardiac diseases. The targeted, chance-free identification and management of traditional vascular risk factors in midlife is a general public health strategy against the onset of mild to severe cognitive impairment in advanced age. This preventive action must be routinely carried out with outmost awareness by physicians in order to be effective. In advanced age, the individually shaped assessment and management of vascular risk factors assumes particular importance as some of them show a strong age-dependent pattern. The relative strategies with this purpose cannot be separated from a thorough lifestyle anamnesis including nutrition, physical exercise, and cognitive and social activities.
Keywords: Alzheimer's disease, cardiac diseases, cognitive impairment, dementia, diabetes, hypercholesterolemia, hypertension, metabolic syndrome, obesity, vascular risk factors
DOI: 10.3233/JAD-2012-120871
Journal: Journal of Alzheimer's Disease, vol. 32, no. 3, pp. 521-530, 2012
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