DAPK1 is Associated with FTD and not with Alzheimer's Disease

Article type: Short Communication

Authors: Tedde, Andrea^{a; *} | Piaceri, Irene^a | Bagnoli, Silvia^a | Lucenteforte, Ersilia^b | Piacentini, Silvia^a | Sorbi, Sandro^a | Nacmias, Benedetta^a

Affiliations: [a] Department of Neurological and Psychiatric Sciences, University of Florence and Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Largo Brambilla, Florence, Italy | [b] Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy

Correspondence: [*] Correspondence to: Andrea Tedde, Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla, 3, Florence 50134, Italy. Tel.: +39 055 4271379; Fax: +39 055 4271380; E-mail: tedde@unifi.it.

Abstract: Apoptosis is correlated with various forms of dementia. Death-associated protein kinase 1 (DAPK1) plays an important role in neuronal apoptosis and could influence the pathology of late-onset Alzheimer's disease (LOAD) and frontotemporal dementia (FTD). It has been reported that two common polymorphisms (rs4878104 and rs4877365) are associated with LOAD, thus we examined the genotype and allele distributions of the above polymorphisms in 681 Italian subjects, including patients with LOAD and FTD. We showed a positive association between rs4878104 and FTD, suggesting a possible implication of the DAPK1 genetic variant in the susceptibility to FTD.

Keywords: Alzheimer's disease, DAPK1, frontotemporal dementia, SNP

DOI: 10.3233/JAD-2012-120556

Journal: Journal of Alzheimer's Disease, vol. 32, no. 1, pp. 13-17, 2012