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Article type: Short Communication
Authors: Ross, Joel S.a | Imbimbo, Bruno P.b; *
Affiliations: [a] Memory Enhancement Center, Eatontown, New Jersey, USA | [b] Chiesi Farmaceutici, Parma, Italy
Correspondence: [*] Correspondence: Dr. Bruno P. Imbimbo, Research and Development Department, Chiesi Farmaceutici, Via Palermo 26/A, 43100 Parma, Italy. Tel.: +39 0521 279278; Fax: +39 0521 279510, E-mail: b.imbimbo@chiesigroup.com.
Abstract: The recent failure of semagacestat in two large Phase III studies questions the value of γ-secretase inhibitors in treating Alzheimer's disease. Understanding the reasons of this setback may be important for the future research on effective treatments for this devastating disease.
DOI: 10.3233/JAD-2010-101548
Journal: Journal of Alzheimer's Disease, vol. 22, no. 2, pp. 401-404, 2010
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