Affiliations: [a] Warsaw University of Life Sciences – SGGW, Warsaw, Poland | [b] Laboratory of Neuropsychology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland | [c] Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland | [d] CSK MSWiA, Warsaw, Poland | [e] Department of Neurodegenerative Diseases, Mossakowski Medical Research Centre, Warsaw, Poland | [f] Institute of Physics, Polish Academy of Sciences, Warsaw, Poland
Correspondence:
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Correspondence to: Danek Elbaum, Institute of Physics, Polish Academy of Sciences, 02-668 Warsaw, Poland, al. Lotnikow 32/46; Fax: +48 22 843 09 26; Email: elbaum@ifpan.edu.pl.
Abstract: Several neurodegenerative diseases, including Alzheimer's disease (AD), have etiology connected to abnormal protein self association. Copper-induced striking differences in amyloid-β40 aggregation, distinct from spontaneous self association, prompted us to study whether amyloid-β40 aggregation could be applied to differentiate between platelet poor plasma ultrafiltrates obtained from AD and control samples. We report, based on 20 AD and 18 age-matched controls, a significant difference in the concentration of short fibers induced by ultrafiltrated plasma from AD compared to control samples. The observed effect was independent of copper and other EDTA chelatable ions.
