Anesthetics Promoting in vitro AβPP Metabolism and Amyloid-β Toxicity

Issue title: Anesthetics and Alzheimer's Disease

Guest editors: Pravat K. Mandalx and Vincenzo Fodaley

Article type: Review Article

Authors: Eckel, Barbara^{; *} | Blobner, Manfred | Rammes, Gerhard

Affiliations: Klinik für Anästhesiologie, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr, München, Germany | [x] Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Manesar, Gurgaon, India | [y] Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico G. Martino, Messina, Italy

Correspondence: [*] Correspondence to: Barbara Eckel, Klinik für Anästhesiologie, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 München, Germany. Tel.: +49 (0)89 4140 4291; Fax: +49 (0)89 4140 4886; E-mail: b.eckel@lrz.tum.de.

Abstract: At present, more than 35 million people worldwide have Alzheimer's disease (AD). With increasing incidence and a growing number of aged patients undergoing surgery, the relevance of a possible interaction between anesthetics and AD is growing as well. Below, we review in vitro studies investigating the effects of anesthetics on the metabolism of amyloid precursor protein and its metabolite amyloid-β.

Keywords: Alzheimer's disease, amyloid, amyloid-β protein precursor, anesthetics, in vitro

DOI: 10.3233/JAD-2010-100984

Journal: Journal of Alzheimer's Disease, vol. 22, no. s3, pp. S21-S26, 2010