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Article type: Short Communication
Authors: Koshy, Beenaa; 1 | Miyashita, Akinorib; 1 | St. Jean, Pamelaa; 1 | Stirnadel, Heidec | Kaise, Toshihikod | Rubio, Justin P.a | Mooser, Vincenta | Kuwano, Ryozob | Irizarry, Michael C.c; *
Affiliations: [a] Genetics, GlaxoSmithKline, Research Triangle Park, NC, USA | [b] Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan | [c] WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA | [d] Epidemiology, GlaxoSmithKline, Tokyo, Japan
Correspondence: [*] Correspondence to: Michael C. Irizarry, M.D., M.P.H., Director, WW Epidemiology, GlaxoSmithKline, 5 Moore Drive, 17.2123, Research Triangle Park, North Carolina 27709, USA. Tel.: +1 919 483 7701; Fax: +1 919 315 4947; E-mail: michael.c.irizarry@gsk.com.
Note: [1] Equal contribution.
Note: [] Handling Associate Editor: Estrella Gómez-Tortosa
Abstract: High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene – PLA2G7 V279F – is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI 0.86–1.12, p = 0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE ε4. Genetic deficiency of Lp-PLA2 activity is not associated with a reduced risk of AD in the Japanese population.
Keywords: Alzheimer's disease, apolipoprotein E, genetic association study, lipoprotein-associated phospholipase A2, Mendelian randomization
DOI: 10.3233/JAD-2010-100513
Journal: Journal of Alzheimer's Disease, vol. 21, no. 3, pp. 775-780, 2010
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