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High Resolution Imaging of the Medial Temporal Lobe in Alzheimer's Disease and Dementia with Lewy Bodies

Article type: Research Article

Authors: Firbank, Michael J.a; * | Blamire, Andrew M.b | Teodorczuk, Andrewa | Teper, Emmaa | Burton, Emma J.a | Mitra, Dipayanc | O'Brien, John T.a

Affiliations: [a] Institute for Ageing and Health, Newcastle University, Newcastle, UK | [b] Newcastle MR Centre, Newcastle University, Newcastle, UK | [c] Department of Neuroradiology, Newcastle General Hospital, Newcastle, UK

Correspondence: [*] Correspondence to: Michael J. Firbank, Institute for Ageing and Health, Newcastle University, Wolfson Research Center, Campus for Aging and Vitality, Newcastle upon Tyne NE4 5PL, UK. Tel.: +44 (0)191 248 1319; Fax: +44 (0)191 248 1301; E-mail: m.j.firbank@ncl.ac.uk.

Note: [] Handling Associate Editor: Marco Bozzali

Keywords: Alzheimer's disease, dementia with Lewy bodies, hippocampus, MRI, subiculum

DOI: 10.3233/JAD-2010-100138

Journal: Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1129-1140, 2010

Accepted 13 May 2010
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Published: 10 September 2010
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Abstract

We used high resolution (0.3 mm in-plane) coronal 3T magnetic resonance (MR) imaging of the medial temporal lobe in 16 subjects with Alzheimer's disease (AD), 16 with dementia with Lewy bodies (DLB), and 16 similarly aged healthy subjects. On the anterior section of the hippocampus body, regions of interest were manually drawn blind to diagnosis on the CA1, CA2, and CA3/4 subregions, and the width of the subiculum and entorhinal cortex was measured. Controlling for intracranial volume, age, and years of education, we found the subiculum thickness was significantly reduced in AD (2.03 ± 0.29 mm) compared to both control (2.37 ± 0.28 mm, p = 0.008) and DLB (2.35 ± 0.24 mm, p = 0.001) subjects. The area of CA1 was likewise reduced in AD compared to controls and DLB. In the hippocampus images, a hypointense line is visible between CA1 and CA3/4. This line was significantly less distinct in AD, suggesting disease related changes to this region. Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB.

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