Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Issue title: Free Radicals and Cell Signaling in Alzheimer's Disease
Guest editors: Alexander Boldyrevx and Peter Johnsony
Article type: Research Article
Authors: Viña, Jose; * | Lloret, Ana | Vallés, Soraya L. | Borrás, Consuelo; 1 | Badía, Mari-Carmen | Pallardó, Federico V. | Sastre, Juan | Alonso, Maria-Dolores; 2
Affiliations: Departamento de Fisiología, Facultad de Medicina, Valencia, Spain | [x] Department of Biochemistry, M.V. Lomonosov Moscow State University, Moscow, Russia | [y] Department of Biomedical Sciences, Ohio University, Athens, OH, USA
Correspondence: [*] Corresponding author: Dr. Jose Viña, Departamento de Fisiología, Facultad de Medicina, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain. Tel.: +34 963 864 650; Fax: +34 963 864 642; E-mail: jose.vina@uv.es
Note: [1] Present address. Universidad Católica de Valencia, Guillem de Castro 94, 46003 Valencia, Spain.
Note: [2] Present address. Department of Neurology, Hospital Clinico Universitario, Avenida Blasco Ibáñez 17, 46010 Valencia, Spain.
Abstract: The role of free radicals in Alzheimer disease pathophysiology has been appreciated for a long time. Originally, radicals were considered as causative of oxidative damage. More recently their role as signalling molecules in this, as well as in other fields of free radical biology, has been underscored. Mitochondria are both generators and targets of radical damage in aging. In this paper we review evidence that radicals generated in mitochondria in the presence of Aβ are signals that trigger both the mitochondrial and the extra-mitochondrial pathways of apoptosis. There are gender specific differences in mitochondrial Aβ toxicity: mitochondria from young (but not from old) females appear to be protected. 17-β Estradiol or phytoestrogens like genistein prevent the formation of oxidants by mitochondria and protect against mitochondrial Aβ toxicity. Experiments reported here indicate that phytoestrogens might have a role in the prevention of Alzheimer's disease.
Keywords: Apoptosis, gender, estrogenic compounds, antioxidants, MAP kinases
DOI: 10.3233/JAD-2007-11205
Journal: Journal of Alzheimer's Disease, vol. 11, no. 2, pp. 175-181, 2007
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl