Affiliations: [a] Otto Wagner Hospital, Department of Pathology, Baumgartner Höhe 1, A-1145, Vienna, Austria | [b] Instiute of Clinical Neurobiology, Kenyongasse 18, A-1070, Vienna, Austria
Correspondence:
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Corresponding author: Dr. Johannes Attems, Otto Wagner Hospital, Department of Pathology, Baumgartner Höhe 1, A-1145 Vienna, Austria. Tel.: +43 1 91060 21308; Fax.: +43 1 91060 49807; E-mail: johannes.attems@wienkav.at.
Abstract: Few studies evaluated cause of death (COD) in elderly demented and non-demented people, the majority based on death certificates alone. The present study is based on autopsy reports with neuropathological examination of 308 inpatients (58.1% female) over age 60 years (mean: 83.5, SD: +/−8.6). CODs were classified into seven groups. The most common were bronchopneumonia (n=117; 38%) and cardiovascular disease (n=116, 37.7%). In 176 patients (57.1%) neuropathology was indicative for dementia: 76.7% Alzheimer disease (AD), 4.5% vascular dementia, 4.0% mixed type dementia (AD + vascular dementia), and 14.8% other dementias. Main COD significantly differed in demented and non-demented patients: bronchopneumonia (45.5% in demented versus 28.0% in non-demented), cardiovascular disease (46.2% in non-demented versus 31.3% in demented). Whereas there were significant differences in COD between AD patients and non-demented ones (bronchopneumonia versus cardiovascular disease), no differences were seen between the latter and patients with other types of dementia than AD. Our data emphasize the high incidence of bronchopneumonia as a COD in patients suffering from AD
Keywords: Cause of death, dementia, Alzheimer disease, autopsy, bronchopneumonia, cardiovascular disease
