Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD⁺ metabolism

Issue title: New Directions in Neuroprotection: Basic Mechanisms, Molecular Targets and Treatment Strategies

Article type: Research Article

Authors: Henricksen, L.A. | Federoff, H.J.^{; *}

Affiliations: Center for Aging and Developmental Biology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine & Dentistry, USA

Correspondence: [*] Corresponding author. E-mail: Howard_Federoff@urmc.rochester.edu.

Abstract: Herein a case is made for the development of novel cytoprotective approaches based upon molecular mechanisms thought to underlie the caloric restriction phenomenon. This analysis leads to the prediction that molecular genetic perturbations affecting the metabolism of nuclear NAD+ and metabolites will be neuroprotective.

DOI: 10.3233/JAD-2004-6S608

Journal: Journal of Alzheimer's Disease, vol. 6, no. s6, pp. S43-S46, 2004