Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes

Article type: Research Article

Authors: Pandya, Jignesh D. | Dave, Kunjan R. | Katyare, Surendra S.^{; *}

Affiliations: Department of Biochemistry, Faculty of Science, M.S.University of Baroda, Vadodara 390 002, India

Correspondence: [*] Corresponding author: Prof. S.S. Katyare, Tel.: +91 0265 795594; Fax: +91 0265 787556; E-mail: pandyajignes@hotmail.com

Abstract: Long-term exposure to AlCl3 resulted in 57% phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%- decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% composition. However, the contents of all phospholipids decreased uniformly by about 70%. fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.

DOI: 10.3233/JAD-2001-3603

Journal: Journal of Alzheimer's Disease, vol. 3, no. 6, pp. 531-539, 2001