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Article type: Research Article
Authors: Wu, Zhengrong | Zhou, Liangjing | Ding, Guoping | Cao, Liping*
Affiliations: Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Correspondence: [*] Corresponding author: Liping Cao, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3, Qingchun Road, Hangzhou, Zhejiang, China. Tel./Fax: +86 0571 86090073; E-mail:caolipingzju@126.com
Abstract: BACKGROUND: The miR-212 was among the top differentially expressed miRNAs in pancreatic ductal adenocarcinoma (PDAC). OBJECTIVE: The aim of this study was to investigate the expression of miR-212 in PDAC and evaluate its correlation with major clinicopathologic features and patients' survival. METHODS: Fluorescence in situ hybridization (FISH) was adopted to examine miRNA expression in 45 pancreatic cancer and 20 normal pancreatic tissues. The relationship of miR-212 expression with clinicopathologic parameters and clinical outcome was evaluated. RESULTS: miR-212 was confirmed to have significantly higher expression in PDAC compared with normal pancreatic tissues (51.1% vs 10%, p< 0.01). High expression of miR-212 was significantly associated with tumor size (p = 0.048) and tumor stage (p = 0.023). Moreover, in univariant analysis, patients with high expression of miR-212 demonstrate significantly poorer overall survival (p= 0.02). CONCLUSIONS: High expression of miR-212 in PDAC is associated with shorter overall survival. It may be not only a potential prognostic marker, but also a possible therapeutic target in PDAC.
Keywords: microRNA-212, Pancreatic neoplasms, Prognosis
DOI: 10.3233/CBM-160671
Journal: Cancer Biomarkers, vol. 18, no. 1, pp. 35-39, 2017
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