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Article type: Research Article
Authors: Wang, Guanghuia; b | Shen, Weia; b | Cui, Longa; b | Chen, Weia; b | Hu, Xuguanga; b | Fu, Jihonga; b; *
Affiliations: [a] Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China | [b] Shanghai Colorectal Cancer Research Center, Shanghai, China
Correspondence: [*] Corresponding author: Jihong Fu, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, China. Fax: +86 21 25077855; E-mail:Fjh720@126.com
Abstract: BACKGROUND: Our previous study found ANLN was over-expressed in colorectal cancer(CRC), however the role of ANLN in CRC remained unknown. OBJECTIVE: To investigate the relationship of ANLN expression in CRC with clinical features and to determinate the prognostic significance of ANLN expression in CRC. METHODS: The ANLN expression in CRC tissue and adjacent normal colorectal mucosa were measured, the relationship between ANLN expression and clinical features as well as overall survival were analyzed. RESULTS: ANLN was overexpressed in CRC. ANLN expression was associated with tumor invasion and enlarged tumor size. Furthermore, Kaplan-Meier survival analysis revealed that higher expression of ANLN was associated with poorer overall survival. Multi-variate analysis suggested that higher expression of ANLN, preoperative CEA level and distant metastasis were independent prognostic factor in patients with CRC CONCLUSIONS: ANLN expression is elevated in CRC and has a strong potential to act as a biomarker for the prognosis of CRC.
Keywords: Colorectal cancer, ANLN, prognosis
DOI: 10.3233/CBM-160585
Journal: Cancer Biomarkers, vol. 16, no. 3, pp. 459-465, 2016
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