Affiliations: [a] School of Clinical Medicine, Dali University, Dali, Yunnan, China | [b] Xichang People’s Hospital, Xichang, Sichuan, China | [c] Affiliated Hospital of Xichang College, Xichang, Sichuan, China
Correspondence:
[*]
Corresponding authors: Yuanyuan Zhang, School of Clinical Medicine, Dali University, Dali 671000, Yunnan, China. Tel.: +86 0872 2201096; E-mail: zhyy@dali.edu.cn. Guangming Wang, School of Clinical Medicine, Dali University, Dali 671000, Yunnan, China. Tel.: +86 0872 2201096, E-mail: wgm1991@dali.edu.cn.
Abstract: BACKGROUND: Cervical cancer (CC) is a malignant tumor threatening women’s health. Replication factor C (RFC) 5 is significantly highly expressed in CC tissues, and the immune microenvironment plays a crucial role in tumor initiation, progression, and metastasis. OBJECTIVE: To determine the prognostic role of RFC5 in CC, analyze the immune genes significantly associated with RFC5, and establish a nomogram to evaluate the prognosis of patients with CC. METHODS: High RFC5 expression in patients with CC was analyzed and verified through TCGA GEO, TIMER2.0, and HPA databases. A risk score model was constructed using RFC5-related immune genes identified using R packages. Combining the risk score model and clinical information of patients with CC, a nomogram was constructed to evaluate the prognosis of patients with CC. RESULTS: Comprehensive analysis showed that the risk score was a prognostic factor for CC. The nomogram could predict the 3-year overall survival of patients with CC. CONCLUSIONS:RFC5 was validated as a biomarker for CC. The RFC5 related immune genes were used to establish a new prognostic model of CC.
