ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis

Article type: Research Article

Authors: Chen, Jiewei^{a; b; 1} | He, Qingmei^{b; 1} | Wu, Peishan^{c; 1} | Fu, Jianchang^{a; b} | Xiao, Yongbo^{a; b} | Chen, Keming^{a; b} | Xie, Dan^{a; b; *} | Zhang, Xinke^{a; b; *}

Affiliations: [a] Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China | [b] Guangdong Esophageal Cancer Institute, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China | [c] Department of Pathology, The Second Affiliated Hospital of Shantou University Medical College, Guangdong, China

Correspondence: [*] Corresponding authors: Dan Xie and Xinke Zhang, Department of Pathology, Sun Yat-sen University Cancer Center, 651# Dong Feng Road East, Guangzhou, Guangdong 510060, China. Tel.: +86 20 87342270; E-mails: xiedan@sysucc.org.cn and zhangxk@ sysucc.org.cn.

Note: [1] These authors contributed equally to this work.

Abstract: BACKGROUND: Zinc finger MYND (Myeloid, Nervy and DEAF-1)-type containing 8 (ZMYND8) is closely correlated with tumor proliferation and invasiveness. However, its prognostic value has not been estimated in colorectal cancer (CRC). OBJECTIVE: We aimed to elucidate the prognostic significance of ZMYND8 expression and the pN and pM classification supplemented by its expression in CRCs. METHODS: The candidate gene ZMYND8 is identified by TCGA database and GEO database, and then we retrospectively evaluated the status and prognostic significance of ZMYND8 expression of 174 patients with CRC. RESULTS: Online data showed high expression of ZMYND8 is closely correlated with worse overall survival. Our study revealed high expression of ZMYND8 in CRC patients was significantly associated with worse overall and disease-free survival (P< 0.05), and was an independently adverse prognostic factor for overall survival (P< 0.001) and disease-free survival (P= 0.001) by univariate and multivariate analysis. C-index to combined prognostic model containing the pN, pM classification supplemented by the status of ZMYND8 expression showed improved predictive ability comparing with the pN and pM classification model (C-index of 0.597 vs. 0.545, respectively). CONCLUSION: The combined prognostic model could improve the ability to determine the clinical outcome of patients with CRC.

Keywords: ZMYND8, prognosis, C-index, colorectal cancer

DOI: 10.3233/CBM-191261

Journal: Cancer Biomarkers, vol. 28, no. 2, pp. 201-211, 2020