Affiliations: [a] Department of Health, Jining First People’s Hospital, Jining, Shandong, China | [b] Department of Gynecology and Obstetrics, Liaocheng People’s Hospital, Liaocheng, Shandong, China | [c] Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Ji’nan, Shandong, China | [d] Department of General surgery, Jining First People’s Hospital, Jining, Shandong, China
Correspondence:
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Corresponding author: Hui Zhang, Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Ji’nan, Shandong, 250012, China. E-mail: zhang15811481@163.com.
Note: [1] Wei Miao and Tan-Min Lu are co-first authors.
Abstract: Ovarian carcinoma ranks fifth in the leading causes of cancer-relevant deaths among the female, with the highest fatality rate in all gynecological malignant tumors and the rising incidence worldwide. Mounting evidence has unveiled that lncRNAs are implicated in the tumorigenesis and cancer development. Several studies have proven the carcinogenic role of SNHG8 in various malignancies, but the physiological functions of SNHG8 in ovarian carcinoma need more detailed explanations. The present study certified that inhibition of SNHG8 executed suppressive activities in ovarian carcinoma by obstructing cell proliferation, migration, EMT process and stemness as well as driving cell apoptosis. Moreover, SNHG8 bound with CAPRIN1 and positively modulated the expression of CAPRIN1. Further experiments manifested that CTNNB1 and Axin1 displayed a binding affinity with CAPRIN1. Knockdown of CAPRIN1 promoted the mRNA degradation of CTNNB1 and Axin1. Finally, we corroborated that CTNNB1 (or Axin1) ectopic expression or activation of Wnt/β-catenin pathway abrogated the effects of SNHG8 downregulation on the cellular process of ovarian carcinoma cells. To summarize, SNHG8 acted as an oncogene in ovarian carcinoma via targeting Wnt/β-catenin pathway, providing a new insight into understanding ovarian carcinoma at the molecular level.
