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Article type: Research Article
Authors: Liu, Yanga; 1 | Li, Linb; 1 | Yu, Jiec | Fan, Yu-Xiaa | Lu, Xiu-Boa; *
Affiliations: [a] Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, Henan, China | [b] Department of Dermatology, The Affiliated Children’s Hospital of Zhengzhou University, Zhengzhou 450002, Henan, China | [c] Department of Ultrasonagraphy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, Henan, China
Correspondence: [*] Corresponding author: Xiu-Bo Lu, Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, Henan, China. Tel.: +86 13526868866; E-mail: luxiubo@zzuresearch.org.
Note: [1] Yang Liu and Lin Li contributed equally to this study and should be considered as co-first authors.
Abstract: BACKGROUND: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy which is generally accompanied by lymph node metastasis. OBJECTIVE: Our study evaluated whether carbon nanoparticle lymph node tracer can improve the outcomes of surgical treatment in papillary thyroid cancer (PTC). METHODS: Ninety-two patients were selected and underwent total thyroidectomy and lymph node resection. Our study placed 45 individuals into the treatment group (carbon nanoparticle group) and 47 cohorts in the control group (no carbon nanoparticle group). RESULTS: Carbon nanoparticle application remarkably improved lymph nodes detection rate in patients (4.7 ± 3.0; P< 0.05) compared to those in control groups (3.5 ± 2.3). The rate of parathyroid accidental resection in the carbon nanoparticle group significantly decreased (6.67%) compared to the control group (21.28%). Incidents of hypoparathyroidism and hypocalcaemia significantly decreased among the carbon nanoparticle cohorts. CONCLUSIONS: Our study definitively showed that carbon nanoparticles can be used to effectively treat lymphatic carcinoma. Our study presented clinical evidences for potential application of carbon nanoparticle in improving the management of PTC patients.
Keywords: Thyroid cancer, papillary thyroid cancer, carbon nanoparticles, carbon nanoparticle lymph node tracer, central region lymph node dissection
DOI: 10.3233/CBM-181386
Journal: Cancer Biomarkers, vol. 23, no. 2, pp. 227-233, 2018
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