Affiliations: [a] Department of Cardiothoracic Surgey Ward 12, Daqing Oil Field General Hospital, Daqing, Heilongjiang 163001, China | [b] Department of Gynaecology Ward 9, Daqing Oil Field General Hospital, Daqing, Heilongjiang 163001, China
Correspondence:
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Corresponding author: Kaichao Wang, Department of Cardiothoracic Surgey Ward 12, Daqing Oil Field General Hospital, Daqing, Heilongjiang 163001, China. Tel.: +86 0459 5805999; E-mail: kaichaowang@sina.com.
Abstract: BACKGROUND:Blood-circulating miRNAs have been reported to act as potential biomarkers in various cancers including non-small cell lung cancer (NSCLC). OBJECTIVE:This study was to assess serum miR-98 levels in NSCLC patients and explore its potential prognostic value. METHODS: The relative expression levels of miR-98 were detected by quantitative RT-PCR in the sera of 127 NSCLC patients and 60 healthy controls. RESULTS: Our results showed that serum miR-98 expression was down-regulated in NSCLC patients compared with healthy controls. Receiver operating characteristic (ROC) curve analysis suggested that serum miR-98 could be used as a potential marker in the diagnosis of NSCLC. In addition, decreased serum miR-98 was positively correlated with worse TNM stage, lymph node metastasis, as well as unfavorable overall survival. Multivariate Cox regression analysis confirmed that serum miR-98 expression was an independent prognostic factor for NSCLC. CONCLUSIONS:Therefore, serum miR-98 might be useful as a promising biomarker for prognosis prediction of NSCLC.
