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Article type: Research Article
Authors: Xue, Liyinga; b | Nan, Jinglongc | Dong, Lib | Zhang, Cuiyingb | Li, Huib | Na, Rentuyab | He, Huijied | Wang, Yadia; e; *
Affiliations: [a] Southern Medical University, Guangzhou, Guangdong, China | [b] Department of Medical Oncology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China | [c] Department of Heart Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China | [d] Department of Pathology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China | [e] Department of Radiation Oncology, Army General Hospital of PLA, Beijing, China
Correspondence: [*] Corresponding authpr: Yadi Wang, Department of Radiation Oncology, Army General Hospital of PLA, 100700, Beijing, China. Tel.: +86 10 66721629; E-mail:yadiwangpla@163.com
Abstract: BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most common cause of cancer-associated mortality. Uncovering novel molecular biomarkers that can predict ESCC development will improve personalized therapy. OBJECTIVE: The goal of the current study was to investigate the expression pattern of miR-483-5p and determine its prognostic value in ESCC. METHODS: We first analyzed miRNA-seq data obtained from the Cancer Genome Atlas (TCGA) cohort to evaluate the prognostic value of miR-483-5p in ESCC. Then quantitative real-time RT-PCR (qRT-PCR) was carried out to compare the miR-483-5p levels in 80 pairs of ESCC tissues and adjacent non-cancerous tissues. The correlation between miR-483-5p levels and clinical features were determined. RESULTS: For the TCGA cohort, ESCC patients with higher miR-483-5p had significantly shorter overall survival time. The examined ESCC cancer tissues exhibited a remarkable increment in miR-483-5p expression compared with the adjacent normal tissues. miR-483-5p was positively correlated with TNM stage, lymph nodes metastasis and T stage. In addition, upregulate miR-483-5p expression was also found to be significantly associated with poor survival of ESCC patients. Furthermore, miR-483-5p expression was an independent prognostic factor for overall survival and disease free survival in ESCC patients. CONCLUSIONS: Our study demonstrates that miR-483-5p might be a tumor promoter of ESCC, which provide a promising prognostic biomarker and therapeutic target.
Keywords: Biomarker, esophageal squamous cell carcinoma, miR-483-5p, prognosis
DOI: 10.3233/CBM-160506
Journal: Cancer Biomarkers, vol. 19, no. 2, pp. 193-197, 2017
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