Affiliations: [a] Department of Infectious Diseases, The Central Hospital of Linyi City, Linyi 276400, Shandong, China | [b] Department of Gastroenterology, The Central Hospital of Linyi City, Liny 276400, Shandong, China | [c] Department of Reproduction, The Central Hospital of Linyi City, Liny 276400, Shandong, China | [d] Department of Nephrology, The Central Hospital of Linyi City, Liny 276400, Shandong, China | [e] Department of Infectious Diseases, Qujing Medical College, Qujing 655000, Yunnan, China
Correspondence:
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Corresponding author: Dr. Xiao-Li Zheng, Department of Infectious Diseases, Qujing Medical College, Sanjiangda Road, Qujing 655000, Yunnan, China. Tel./Fax.: +86 874 3415657; E-mail: zhengxiaoliqj@126.com.
Abstract: OBJECTIVE: The study aims to evaluate the predictive value of microRNA-143 (miR-143) for the prognosis of patients with hepatocellular carcinoma (HCC). METHODS: Between October 2010 and October 2012, 131 HCC patients were selected as a case group; meanwhile, 122 healthy controls were enrolled as a control group. The miR-143 expression in serum was detected by quantitative real-time polymerase chain reaction (qRT-PCR). These HCC patients were divided into the high miR-143 expression group and the low miR-143 expression group based on the threshold of receiver operating characteristic (ROC) curve. Kaplan-Meier method was applied to analyze the prognosis of HCC patients. RESULTS: MiR-143 exhibited decreased expression in the case group significantly compared to the control group. The areas under the ROC curve (AUC), sensitivity value and specificity value of the miR-143 expression for the diagnosis of HCC were 0.831, 80.30% and 82.40%, respectively. The miR-143 expression was negatively correlated with vascular invasion, TNM staging, tumor recurrence, metastasis and survival of HCC patients. CONCLUSIONS:Our study provides evidence that miR-143 may be negatively correlated with the prognosis of HCC and provides a promising strategy for HCC treatment and prognosis improvement.
Keywords: MicroRNA-143, hepatocellular carcinoma, prognosis, predictive value
