Autoantibodies against heat shock proteins as biomarkers for the diagnosis and prognosis of cancer

Article type: Other

Authors: Shi, Liu | Chevolot, Yann | Souteyrand, Eliane | Laurenceau, Emmanuelle^*

Affiliations: Institut des Nanotechnologies de Lyon INL-UMR5270, Université de Lyon, Ecully, France

Correspondence: [*] Corresponding author: Emmanuelle Laurenceau, Institut des Nanotechnologies de Lyon INL-UMR5270, Université de Lyon, CNRS, Ecole Centrale de Lyon, Ecully, F-69134, France. Tel.: +33 4 72 18 62 40; Fax: +33 4 78 33 15 77; E-mail:emmanuelle.laurenceau@ec-lyon.fr

Abstract: Thanks to their specificity and stability in the sera, autoantibodies (AAbs) against tumor-associated antigens (TAAs) are very attractive biomarkers for the development of less invasive serological tests for the diagnosis and prognosis of cancer. Heat shock proteins (HSP) belong to TAAs and they are over-expressed in various human cancers. Elevated HSP can stimulate the immune system to produce anti-HSP antibodies. So far, AAbs against HSP have been identified in the circulation of various cancer patients. Here we will review current literature on the use of anti-HSP antibodies for cancer diagnosis and prognosis. The challenges as well as future directions of AAbs identification in oncology are also discussed.

Keywords: Heat shock proteins, autoantibodies, cancer, diagnosis, prognosis

DOI: 10.3233/CBM-160117

Journal: Cancer Biomarkers, vol. 18, no. 2, pp. 105-116, 2017