Issue title: Adrenergic Signaling and Cancer: Deciphering the Connections
Guest editors: Amal Melhem-Bertrandtx and Anil K. Soody
Article type: Research Article
Authors: Yang, Eric V.a; b; c; * | Eubank, Tim D.c; d; *
Affiliations: [a] Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, USA | [b] Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA | [c] Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA | [d] Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA | [x] Department of Breast medical Oncology, M.D. Anderson Cancer Center, Houston, TX, USA | [y] Department of Gynecologic Oncology, M.D. Anderson Cancer Center, Houston, TX, USA
Correspondence:
[*]
Corresponding authors: Eric V. Yang, Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, 460 Medical Center Drive, Room 120B, Columbus, OH 43210, USA. Tel.: +1 614 293 3129; Fax: +1 614 366 2097; E-mail: Eric.Yang@osumc.edu; Tim D. Eubank, Ph.D. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Room 430 Davis Heart and Lung Research Institute, 473 W. 12th Avenue, Columbus OH 43210, USA. Tel.: +1 614 292 9958; Fax: +1 614 688 4662; E-mail: Tim.Eubank@osumc.edu.
Abstract: Studies suggest that psychosocial factors can impact cancer progression. Parallel work in the fields of psychoneuroimmunology and developmental neuroscience have led to the implication of catecholamine hormones (norepinephrine and epinephrine) and their receptors (the β-adrenergic receptors; β-ARs) in regulating cancer progression. In this review we discuss studies that describe the effects of psychological stress as mediated by factors including the catecholamines norepinephrine and epinephrine on various aspects of tumor progression including proliferation, angiogenesis, and metastasis. We discuss the role of β-ARs in facilitating these effects and the potential use of β-blockers in adjuvant cancer therapy.
Keywords: Catecholamines, adrenergic receptors, β-blockers, skin cancer
DOI: 10.3233/CBM-130325
Journal: Cancer Biomarkers, vol. 13, no. 3, pp. 155-160, 2013
