An updated meta-analysis of XRCC4 polymorphisms and cancer risk based on 31 case-control studies

Article type: Research Article

Authors: Shao, Ning^a; | Jiang, Wen Yu^b; | Qiao, Di^a; | Zhang, Shi Ge^a | Wu, Ye^a | Zhang, Xiang Xiang^a | Hua, Li Xin^c | Ding, Yi^{a; *} | Feng, Ning Han^{c; *}

Affiliations: [a] Department of Urology, Jiangsu Province Geriatric Hospital, Nanjing, China | [b] Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China | [c] Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Correspondence: [*] Correspondence authors: Yi Ding, Department of Urology, Jiangsu Province Geriatric Hospital, 65 Jiangsu Road, Nanjing 210024, China. NingHan Feng, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. E-mail: noideal1@sina.com.

Note: [1] These authors contributed equally to the present work and each is considered first author.

Abstract: Objective:Evidence is accumulating that several genes encoding DNA repair molecules may be cancer-susceptibility genes. Recently, SNPs in XRCC4, a member of DNA repair genes, have been implicated in altering the risk of various cancers. However, the results of these studies are inconclusive or controversial. To derive a more precise estimation, we performed an updated meta-analysis. Methods:A comprehensive search was conducted to examine all the eligible studies about XRCC4 polymorphism and cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Results:We included 31 studies investigated 8 SNPs in XRCC4. Overall, our paper showed significant associations between the rs28360071, rs2075686 polymorphisms and cancer risk. In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis. Conclusions:We conducted a systematic search and combined the available results in this meta-analysis, which provided evidence of the associations between SNPs in XRCC4 and cancer risk. The results suggested that rs28360071 polymorphisms were significantly associated with cancer risk. However, future studies are needed to investigate molecular mechanisms underlying the biological functions of XRCC4 SNPs in cancer development.

Keywords: XRCC4, polymorphism, cancer risk

DOI: 10.3233/CBM-120292

Journal: Cancer Biomarkers, vol. 12, no. 1, pp. 37-47, 2013