Affiliations: [a] Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada | [b] Atlantic Cancer Research Institute, Moncton, NB, Canada | Department of Chemistry and Biochemistry, Université de Moncton, 18 Antonine-Maillet Avenue, Moncton, New Brunswick, Canada E1A 3E9
Note: [1]
The first two authors have contributed equally to the writing of the manuscript.
Abstract: Cancer statistics show significant diagnosis numbers amongst men and women worldwide, where breast cancer is by far the most frequently diagnosed cancer in women. Multiple mechanisms and molecules have been shown to occupy major roles in cancer progression and aggressivity. Recently, small non-coding RNA molecules, called micro-RNAs, have become the subject of interest in many molecular pathways in relation to breast cancer, amongst many other pathologies. MiRNAs are capable of regulating gene expression in a sequence-specific manner and regulate diverse expression patterns which are dependent on the cell’s state and identity. Studies have brought forward specific miRNAs that have the innate ability to govern unique gene expression profiles regulating cancer cell aggressivity. This review will outline recent findings of characterized miRNAs in relation to their molecular targets leading to cancer malignancy and progression. More specifically, we will focus on miRNAs associated with breast cancer metastatic processes including epithelial to mesenchymal and mesenchymal to epithelial transitioning (EMT/MET transition), migration, invasion and angiogenesis.
Keywords: miRNA, breast cancer, metastasis, migration, invasion, EMT, MET, angiogenesis
