The mitochondrial permeability transition

Article type: Research Article

Authors: Bernardi, Paolo^; | Colonna, Raffaele | Costantini, Paola | Eriksson, Ove | Fontaine, Eric | Ichas, François | Massari, Stefano | Nicolli, Annamaria | Petronilli, Valeria | Scorrano, Luca

Affiliations: CNR Unit for the Study of Biomembranes and Department of Biomedical Sciences, University of Padova Medical School, Viale G. Colombo 3, I‐35121 Padova, Italy

Note: [] Correspondence to: Prof. Paolo Bernardi, Department of Biomedical Sciences, Viale G. Colombo 3, I‐35121 Padova, Italy. Fax: +39 049 827 6361; E‐mail: bernardi@civ.bio.unipd.it.

Abstract: This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A‐sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.

Journal: Biofactors, vol. 8, no. 3-4, pp. 273-281, 1998