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Article type: Research Article
Authors: Yang, Jeong-Yeh | Della-Fera, Mary Anne | Rayalam, Srujana | Ambati, Suresh | Baile, Clifton A.;
Affiliations: Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA | Department of Foods and Nutrition, University of Georgia, Athens, GA, USA
Note: [] Address for correspondence: Clifton A. Baile, 444 Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA 30602-2771, USA. Tel.: +1 706 542 2771; Fax: +1 706 542 7925; E-mail: cbaile@uga.edu
Abstract: Genistein (G), an isoflavone, and guggulsterone (GS), the active substance in guggulipid, have been reported to possess therapeutic effects for obesity. In the present study, we investigated the effects of combinations of G plus GS on apoptosis and adipogenesis in 3T3-L1 cells. In mature adipocytes, G and GS individually caused apoptosis, but combination of G plus GS significantly increased apoptosis, more than either compound alone. Furthermore, G plus GS caused a greater increase in procaspase-3 cleavage, Bax expression, cytochrome c release, and proteolytic cleavage of PARP than either compound alone. In maturing preadipocytes G and GS each suppressed lipid accumulation, but the combination potentiated the inhibition of lipid accumulation. These results suggest that combination of genistein and guggulsterone may exert anti-obesity effects by inhibiting adipogenesis and inducing apoptosis in adipocytes.
Keywords: Genistein, guggul, 3T3-L1 adipocytes, apoptosis, cytochrome c, mitochondria, adipogenesis
Journal: BioFactors, vol. 30, no. 3, pp. 159-169, 2007
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