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Article type: Research Article
Authors: Hamano, Hiroki | Yoshinaga, Koji | Eta, Runa | Emori, Yutaka | Kawasaki, Daisuke | Iino, Yuka | Sawada, Miwa | Kuroda, Hiroyuki | Takei, Mineo
Affiliations: Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan
Note: [] Address for correspondence: Hiroki Hamano, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., 2512-1, Oshikiri, Kohnan-machi, Ohsato-gun, Saitama 360-0111, Japan. Tel.: +81 48 536 3456; Fax: +81 48 539 1072; E-mail: hiroki-hamano@zeria.co.jp
Abstract: The effect of polaprezinc, a chelate compound consisting of zinc ion and L-carnosine, on abnormalities of taste sensation induced by feeding a zinc-deficient diet to rats was examined by using the two-bottle preference test (quinine hydrochloride as a bitter taste and sodium chloride as a salty taste). Rats were fed either a zinc-deficient or a zinc-sufficient diet. The zinc-deficient diet increased the preference for both taste solutions, while polaprezinc (at doses of 3 and 10 mg/kg) restored the altered taste preferences. We also evaluated the proliferation of taste bud cells using 5-bromo-2'-deoxyuridine (BrdU). The BrdU incorporation into taste bud cells was significantly reduced in rats fed a zinc-deficient diet compared with rats fed a zinc-sufficient diet (from 50.8% to 45.0%, p<0.05) and this reduction was reversed by polaprezinc at doses of 1, 3, and 10 mg/kg, increasing to 50.2%, 53.5%, and 52.5%, respectively. These findings indicate that zinc deficiency induces the delayed of proliferation of taste bud cells, while polaprezinc improves cell proliferation. In conclusion, polaprezinc had a therapeutic effect in a rat model of abnormal taste sensation. Its mechanism of action was suggested to involve improvement of the decrease in taste bud cell proliferation caused by zinc deficiency.
Keywords: Taste disorder, zinc, two-bottle preference test, taste bud cell proliferation, rat, Z-103
Journal: BioFactors, vol. 28, no. 3-4, pp. 185-193, 2006
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