Coenzyme Q, Vitamin E and Apo-E alleles in Alzheimer Disease

Issue title: The Third Conference of the International CoQ10 Association

Article type: Research Article

Authors: Battino, M. | Bompadre, S. | Leone, L. | Devecchi, E. | Degiuli, A. | D'Agostino, F. | Cambiè, G. | D'Agostino, M. | Faggi, L. | Colturani, G. | Gorini, A. | Villa, R.F.

Affiliations: Institute of Biochemistry, Università Politecnica delle Marche, Faculty of Medicine, Ancona, Italy | Institute of Microbiology and Biomedical Sciences, Università Politecnica delle Marche, Faculty of Medicine, Ancona, Italy | Immuno-Haematology & Transfusion Department, General Hospital of Lodi, Italy | U.O. of Neurology, General Hospital of Lodi, Italy | Department of Physiological-Pharmacological Sciences, Division of Pharmacology and Pharmacological Biotechnologies, Laboratory of Neurochemistry and Molecular Medicine, University of Pavia, Pavia, Italy

Note: [] Address for correspondence: Dr. Maurizio Battino, PhD, DSc, Institute of Biochemistry, Faculty of Medicine, Università Politecnica delle Marche, Via Ranieri, 65, 60100 Ancona, Italy. Tel.: +39 071 2204646; Fax: +39 071 2204398; E-mail: mbattino@unian.it

Abstract: Neurodegenerative Diseases represent the most commmon cause of Dementia, about 5–10% of the population aged above 65 years and about 30% above 80 years. A study about Apo-E alleles, Coenzyme Q and Vitamins E as biological indicators was performed in plasma samples of patients aged from 30 to 85 years, affected by Neurodegenerative Diseases. The results were compared with control subjects of approximately the same ages as the reference group. A frequency of 21.7% of ε4 allele in control group was estimated, against 15.8% observed in patients. The frequency of ε2 and ε3 alleles was 13.0% and 65.2% in the control group against 10.5% and 73.7% in patients. No significant differences were observed between the frequency of ε3/ε3 genotype and ε3/ε4 genotype in the control group compared to patients' group. The frequencies observed in ε2/ε3 genotype groups were 8.7% vs 15.8% and of e2/e4 genotype 17.4% vs 5.3%. The ε2/ε2 and ε4/ε4 genotypes were not identified in any groups. Plasma CoQ_{10} concentrations were similar in patient and control groups and no differences were found even taking into account the distribution of male and female subjects in the two groups. Also, vitamin E did not provide evidence of any differences between groups and the analysis among sexes revealed that again vitamin E concentrations were similar in between subgroups.

Keywords: coenzyme Q, Vitamin E, Alzheimer, ApoE

Journal: BioFactors, vol. 18, no. 1-4, pp. 277-281, 2003