Affiliations: Department of Endocrinology and Metabolic Diseases,
Leiden University Medical Center, Leiden, The Netherlands | Human and Animal Physiology Group, Wageningen
University, Wageningen, The Netherlands
Note: [] Address for correspondence: Janny P. Schröder-van der Elst,
Department of Endocrinology and Metabolic Diseases, Leiden University Medical
Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Tel.: +31 71 5262173;
Fax: +31 71 5248136; E-mail: J.P.van_der_Elst@LUMC.nl
Abstract: Flavonoids have inhibiting effects on the proliferation of cancer
cells, including thyroidal ones. In the treatment of thyroid cancer the uptake
of iodide is essential. Flavonoids are known to interfere with iodide
organification in vitro, and to cause goiter. The influence of flavonoids
on iodine metabolism was studied in a human thyroid cancer cell line (FTC-133)
transfected with the human sodium/iodide transporter (NIS). All flavonoids
inhibited growth, and iodide uptake was decreased in most cells. NIS mRNA
expression was affected during the early hours after treatment, indicating that
these flavonoids can act on NIS. Pendrin mRNA expression did not change after
treatment. Only myricetin increased iodide uptake. Apeginin, luteolin,
kaempferol and F21388 increased the efflux of iodide, leading to a decreased
retention of iodide. Instead myricetin increased the retention of iodide; this
could be of use in the radioiodide treatment of thyroid cancer.
