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Article type: Research Article
Authors: Zhang, Jin-Song; | Gao, Xue-Yun | Zhang, Li-De | Bao, Yong-Ping
Affiliations: Institute of Solid Physics, Chinese Academy of Science, Hefei, 230031, P.R. China | Nutrition, Health & Consumer Science Division, Institute of Food Research, Norwich, NR4 7UA, UK
Note: [] Institute of Food Research, Norwich, NR4 7UA, UK. Tel.: +44 1603 255194; Fax: +44 1603 507723; E-mail: yongping.bao@bbsrc.ac.uk
Abstract: A novel selenium form, nano red elemental selenium (Nano-Se) was prepared by adding bovine serum albumin to the redox system of selenite and glutathione. Nano-Se has a 7-fold lower acute toxicity than sodium selenite in mice (LD_{50} 113 and 15 mg Se/kg body weight respectively). In Se-deficient rat, both Nano-Se and selenite can increase tissue selenium and GPx activity. The biological activities of Nano-Se and selenite were compared in terms of cell proliferation, enzyme induction and protection against free racial-mediated damage in human hepatoma HepG2 cells. Nano-Se and selenite are similarly cell growth inhibited and stimulated synthesis of glutathione peroxidase (GPx), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and thioredoxin reductase (TR). When HepG2 cells were co-treated with selenium and glutathione, Nano-Se showed less pro-oxidative effects than selenite, as measured by cell growth. These results demonstrate that Nano-Se has a similar bioavailability in the rat and antioxidant effects on cells.
Journal: BioFactors, vol. 15, no. 1, pp. 27-38, 2001
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