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Article type: Research Article
Authors: Förstl, H.; | Levy, R. | Burns, A. | Luthert, P. | Cairns, N.
Affiliations: Section of Old Age Psychiatry, Institute of Psychiatry, London, UK | Department of Neuropathology, Institute of Psychiatry, London, UK | MRC Alzheimer's Disease Brain Bank, Institute of Psychiatry, London, UK
Note: [] Correspondence to: H. Förstl, Central Institute of Mental Health, PO Box 122120, J5, 68159 Mannheim, Germany
Abstract: Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings for the hippocampo-parahippocampo-parietal neuron counts and Variable II with high loadings for coeruleo-frontal cell numbers. Both may reflect functional neuroanatomical connections which may act as pathways of neurodegeneration in AD. A cluster analysis based on these neuron numbers yielded three groups of patients: Cluster A with low hippocampo-parahippocampo-parietal cell counts, Cluster B with well-preserved neuron numbers, and Cluster C with low coeruleo-frontal neuron numbers. Differences in clinical features between these patient groups indicated the potential clinical relevance of these clusters.
Keywords: Alzheimer's disease, neurodegeneration, sub-groups, neuropathology
DOI: 10.3233/BEN-1994-73-411
Journal: Behavioural Neurology, vol. 7, no. 3-4, pp. 175-180, 1994
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