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Article type: Research Article
Authors: Gleichgerrcht, Ezequiel | Cervio, Andrés | Salvat, Jorge | Loffredo, Anselmo Rodríguez | Vita, Luciana | Roca, María; | Torralva, Teresa; | Manes, Facundo;
Affiliations: Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina | Raúl Carrea Institute, Buenos Aires, Argentina | Institute of Neuroscience, Favaloro University, Buenos Aires Argentina
Note: [] Corresponding author: Dr. Facundo Manes, Institute of Cognitive Neurology (INECO), Castex 3293, Buenos Aires, Argentina. Tel./Fax: +54 (11) 4807 4748; E-mail: fmanes@neurologiacognitiva.org
Abstract: The aim of this investigation was to evaluate improvement of executive functions after shunt surgery in patients with early normal pressure hydrocephalus (NPH). Patients with NPH were assessed before and after shunt surgery with tests shown to be sensitive to damage to the prefrontal cortex (PFC). Significant differences were found between basal and follow-up performances on the Boston Naming Test, the backwards digits span, Part B of the Trail Making Test, and the number of words produced on the phonological fluency task. In conclusion, our study reveals that patients with NPH who respond positively to continuous slow lumbar cerebral spinal fluid drainage and receive a ventriculoperitoneal shunt implant, improve their performance on tasks of executive function. Due to the high demand for this form of mental processing in real-life complex scenarios, and based on the severe executive deficits present in both demented and non-demented NPH patients, we encourage the assessment of executive functions in this clinical group.
Keywords: Normal pressure hydrocephalus, ventriculoperitoneal shunt, neuropsychological testing, executive functions, cognitive recovery
DOI: 10.3233/BEN-2009-0249
Journal: Behavioural Neurology, vol. 21, no. 3-4, pp. 181-185, 2009
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