Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Kito, Yumiko | Kazui, Hiroaki | Kubo, Yoshihiko; | Yoshida, Tetsuhiko; | Takaya, Masahiko | Wada, Tamiki | Nomura, Keiko | Hashimoto, Mamoru; | Ohkawa, Shingo; | Miyake, Hiroji | Ishikawa, Masatsune; | Takeda, Masatoshi
Affiliations: Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita-city, Osaka, Japan | Department of Psychiatry, Japan Labour Health and Welfare Organization Kansai Rousai Hospital, Amagasaki-city, Hyogo, Japan | Department of Psychiatry, National Hospital Organization Osaka National Hospital, Chuo-ku, Osaka-city, Osaka, Japan | Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Himeji-city, Hyogo, Japan | Department of Psychiatry and Neuropathobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Kumamoto, Japan | Ohue Hospital, Asagoshi-cho, Asagoshi-city, Hyogo, Japan | Nishinomiya Kyoritsu Neurosurgical Hospital, Nishinomiya-city, Hyogo, Japan | Department of Neurosurgery, Kitano Hospital, Kita-ku, Osaka-city, Osaka, Japan | Department of Neurosurgery, Rakuwakai Otowa Hospital, Yamashina-ku, Kyoto-city, Kyoto, Japan
Note: [] Corresponding author: Hiroaki Kazui, M.D., Ph.D. Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3 2–2 Yamadaoka, Suita-city, Osaka, 565-0871, Japan. Tel.: +81 6 6879 3051; Fax: +81 6 6879 3059; E-mail: kazui@psy.med.osaka-u.ac.jp
Abstract: Objective: To clarify the characteristics of neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus (iNPH). Methods: Neuropsychiatric symptoms of 64 iNPH patients with mild triad symptoms from three kinds of hospitals were evaluated with the Neuropsychiatric Inventory (NPI) and compared with 126 patients with Alzheimer's disease (AD). Results: The most frequently observed neuropsychiatric symptom in the iNPH patients was apathy followed by anxiety and aggression. No symptom was more prevalent or more severe in iNPH than in AD. The severity of cognitive impairment was correlated with both aberrant motor activity and apathy. Conclusions: Neuropsychiatric symptoms were mild in patients with iNPH and apathy was the most prevalent symptom. The correlation between neuropsychiatric symptoms and cognitive impairment in iNPH appears to arise from a common pathology in the frontal lobe.
Keywords: idiopathic normal pressure hydrocephalus, neuropsychiatric symptoms, apathy, Neuropsychiatric Inventory (NPI), Alzheimer's disease
DOI: 10.3233/BEN-2009-0233
Journal: Behavioural Neurology, vol. 21, no. 3-4, pp. 165-174, 2009
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl