Affiliations: Department of Neurology, Drake Center and University
of Cincinnati, 151 West Galbraith Road, Cincinnati, OH 45216, USA | Department of Psychology, University of Cincinnati,
Cincinnati, OH 45219, USA
Note: [] Corresponding author: Susan H. Pierson, MD, Drake Center and
University of Cincinnati, Department of Neurology, 130 North Street, Hyannis,
MA 02601, USA. Tel.: +1 508 771 0006; Fax: +1 508 790 8337; E-mail:
SPierson@CapeCodHealth.org
Abstract: Cognitive impairment in multiple sclerosis is an increasingly
recognized entity. This article reviews the cognitive impairment of multiple
sclerosis, its prevalence, its relationship to different types of multiple
sclerosis, and its contribution to long-term functional prognosis. The
discussion also focuses on the key elements of cognitive dysfunction in
multiple sclerosis which distinguish it from other forms of cognitive
impairment. Therapeutic interventions potentially effective for the cognitive
impairment of multiple sclerosis are reviewed including the effects of disease
modifying therapies and the use of physical and cognitive interventions.
