Affiliations: Bioelectronics Laboratory, Bioelectronics and Neurobioengineering Group, Department of Biophysical and Electronic Engineering (D.I.B.E.), University of Genoa, Via Opera Pia 11 a, 16145, Genova, Italy. Tel.: +3910 3532761; Fax: +3910 3532133
Correspondence:
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Corresponding author.
Abstract: The main purpose of this paper is to describe several software tools specifically adapted to characterize the electrophysiological behavior of a population of neurons coupled to a planar array of microtransducers by analyzing the recorded signals. Both graphic and signal processing tools are considered. They include: image analysis of the neuronal network topology, peak detection procedure, multi-graphics visualization, spike classification, cross-correlation, interspike and interbursting interval analysis. These tools are utilized to characterize changes induced in the electrophysiological behavior of populations of cultured neurons by modifications to the medium-culture.
Keywords: Cell culture, neuronal networks, electrophysiological signals, signal and image processing
