Affiliations: [a]
National Technical University of Athens, Department of Electrical and Computer Engineering, Telecommunication Laboratory, GR 157 73 Athens, Greece | [b] Department of Cardiology, Hippokratio hospital, University of Athens, Citycode, Greece | [c]
National Technical University of Athens, Department of Electrical and Computer Engineering, Biomedical Engineering Laboratory, GR 10682 Athens, Greece
Correspondence:
[*]
Corresponding author.
Abstract: Every aspect of cardiac function such as contractibility, depolarization and repolarization of cardiac cells, firing rate of pacemaker cells, is under a complex neurohumoral regulation. Especially the autonomic neuron system through the interplay of its two opposing components, sympathetic and parasympathetic (vagal), is controlling cardiac function on a beat to beat basis. Moreover, the interaction of sympathetic and parasympathetic systems is a non-linear function, with sympathetic tone modulating the responce of vagal activation. It has been shown that the power of frequency components and especially the ratio of low to high frequency power spectra of heart rate variability are reliable indicators of sympathovagal balance (A. Malliani et al. 1991. Cardiovascular Neural regulation explored in the frequency domain. Circulation, 84 (2) 482–484. The most known algorithms of linear and non-linear signal processing have been applied to the ECG data recorded from healthy and high risk individuals. These methods together with the study and analysis of QRS frequency spectrum will lead to very useful conclusions with diagnostic and prognostic information. In this paper we will briefly describe the mathematical aspect of these algorithms presenting their results for normal and pathological ECG signals.
