Analysis of the cluster efficacy and prescription characteristics of traditional Chinese medicine intervention for non-small cell lung cancer based on a clustering algorithm

Article type: Research Article

Authors: Hong, Mei^a | Sun, Wen-Hao^b | Lu, Ming^{b; c} | Zhong, Tao-Li^b | Chen, Tian-Yuan^b | Zhao, Yi-Dong^b | Hong, Nan^b | Zhu, Yao^{b; *} | Ding, Yi-Yan^{d; *}

Affiliations: [a] Department of Radiation Oncology, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China | [b] Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China | [c] Nanjing Medical Data Mining Center, Nanjing, Jiangsu, China | [d] Department of Traditional Chinese and Western Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

Correspondence: [*] Corresponding authors: Yao Zhu, Nanjing University of Traditional Chinese Medicine, No. 282 Hanzhong Road, Gulou District, Nanjing, Jiangsu 210023, China. E-mail: zhuyao7yao@126.com. Yi-Yan Ding, Department of Traditional Chinese and Western Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, No. 215 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China. E-mail: dingyiyan3972@outlook.com.

Abstract: BACKGROUND: In recent years, malignant tumors have gradually become one of the main causes of death for Chinese residents, of which lung cancer ranks first in both the incidence and mortality in China. OBJECTIVE: To mine the text of traditional Chinese medicine (TCM) clinical medical cases after data cleaning, analyze it, and study the experience of TCM doctors in treating non-small cell lung cancer (NSCLC). METHODS: The applied approach was based on the data mining methods of decentralized and hierarchical system clustering of data from a drug and prescription database. This study involved 215 patients, 287 cases, and 147 types of clinical drugs. RESULTS: The data analysis of the clinical treatment of NSCLC in TCM showed that Erchen Decoction was the main method for the treatment of non-small cell lung cancer in clinical treatment of non-small cell lung cancer. Junjian recipes were close to each other, with Banzhilian, Lobelia, Shanci Mushroom, Hedyotis diffusa to anticancer and detoxify. CONCLUSION: This study analyzed the core TCM prescription for NSCLC by collecting the empirical essence and characteristics of specific medications. It has some guiding scientific significance for the clinical treatment of lung cancer.

Keywords: Traditional Chinese medicine medical records, cluster analysis, non-small cell lung cancer, clinical experience, data mining, clinical research

DOI: 10.3233/THC-220644

Journal: Technology and Health Care, vol. 31, no. 5, pp. 1759-1770, 2023